Apr 16, 2012
Phosphoinositide 3-kinase (PI3K) and its phospholipid products are polarized toward the front of migrating fibroblasts, but their exact function in persistent motility remains unclear. Welf et al. reveal that PI3K signaling helps reorient migrating fibroblasts by stabilizing branched protrusions at the leading edge, allowing the cell to pivot and move in a different direction. This biosights episode presents the paper by Welf et al. from the April 2, 2012, issue of The Journal of Cell Biology and includes an interview with senior author Jason Haugh (North Carolina State University, Raleigh, NC). Produced by Caitlin Sedwick and Ben Short. See the associated paper in JCB for details on the funding provided to support this original research.
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