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Jul 6, 2015

Interphase centrosomes flare up

Centrosomes undergo dramatic changes in size and structure during the rapid cell cycles of early Drosophila embryos. Lerit et al. reveal that a scaffold formed by the proteins centrosomin and PLP is required to maintain the activity of interphase centrosomes, which is essential for nuclear spacing and proper chromosome segregation. This biosights episode presents the paper by Lerit et al. from the July 6th, 2015, issue of The Journal of Cell Biology and includes an interview with two of the paper's authors, Dorothy Lerit and Nasser Rusan (National Heart, Lung, and Blood Institute, Bethesda, MD). Produced by Caitlin Sedwick and Ben Short. See the associated paper in JCB for details on the funding provided to support this original research.


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