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Jun 5, 2017

Broken chromosomes stay on the safe side in mitosis

Unrepaired DNA double strand breaks can generate chromosome fragments that lack centromeres but, surprisingly, these acentric chromosomes can nevertheless segregate to spindle poles during mitosis. Karg et al. reveal that, in Drosophila melanogaster neuroblasts, acentric chromosomes segregate along interpolar microtubules at the spindle periphery that are organized by the chromokinesin motor protein Klp3a. This biosights episode presents the paper by Karg et al. from the June 5th, 2017, issue of The Journal of Cell Biology and includes an interview with the paper's senior author, William Sullivan (University of California, Santa Cruz). Produced by Caitlin Sedwick and Ben Short. See the associated paper in JCB for details on the funding provided to support this original research.


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