Jan 23, 2012
T cells require the septin family of GTP-binding proteins to maintain the integrity of their plasma membranes as they invade through tissues. Gilden et al. reveal that septins function by assembling on membrane blebs to retract them back into shape. This biosights episode presents the paper by Gilden et al. from the January 9, 2012, issue of the Journal of Cell Biology and includes an interview with senior author Max Krummel (University of California, San Francisco). Produced by Caitlin Sedwick and Ben Short. See the associated paper in JCB for details on the funding provided to support this original research.
The Rockefeller University Press