Mar 14, 2016
Fat2 whips fly eggs into shape
During Drosophila oogenesis, the collective migration of egg chamber follicle cells drives the chambers' rotation and elongation. Squarr et al. reveal that the atypical cadherin Fat2 recruits the WAVE regulatory complex to tricellular junctions to induce the formation of whip-like actin protrusions that control collective migration and tissue rotation. This biosights episode presents the paper by Squarr et al. from the February 29th, 2016, issue of The Journal of Cell Biology and includes an interview with the paper's senior author, Sven Bogdan (University of Münster, Münster, Germany). Produced by Caitlin Sedwick and Ben Short. See the associated paper in JCB for details on the funding provided to support this original research.
The Rockefeller University Press